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KMID : 0603520010060010019
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Journal of Korean Association of Cancer Prevention
2001 Volume.6 No. 1 p.19 ~ p.25
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Tumor Suppress Effects of Extracts from Ulmus pumila, eriobotrya japonica, and Artemisia capillaris Thunb in Nude Mice
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Lee Sun-Young
Lee Chan
Kim In-Ho
Ruy Jae-Oong
Lim Jun-Kyu
Kim Sang-Woo
Choi Seung-Ki
Kim Se-Hyun
Oh Yu-Kyoung
Kim Seung-Jo
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Abstract
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Ulmus pumila, Eriobotrya japonica Lindl, and Artemisia capillaris Thunb have been used as anticancer folk medicines in Korea. In this study, we report the suppress effects of the extracts obtained from these herbs against tumors in nude mice. HeLa cells were injected into the nude mice after 1 month of oral pretreatment with usual care diet, nutritious raw food, or the mixture of usual diet and herbal extract in a pellet form. After injection of HeLa cells, the nude mice received either usual care diet, nutritious raw food, or the mixture of usual diet supplemented with the herbal extracts for two months. After tumor induction, the weight change of the nude mice were significantly lower in herbal extract-treated groups than the nutritious raw food group or the control group given usual care diet throughout the experiments. The herbal extracts suppressed the growth of tumors in nude mice, showing as high as 50% and 34% of tumor size reduction at one month and two months after tumor induction, respectively. These results indicate the potential use of the extract obtained from Ulmus pumila, Eriobotrya japonica, and Artemisia capillaris Thunb as a food supplement for cancer patients.
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KEYWORD
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Herbal extracts, Ulmus, Eriobotrya, Artemisia, HeLa cell, Nude mice, Tumor growth, Suppress effects
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